Moving Digital Images

For over six years the Marquette University Archives managed patron-driven scanning requests using a desktop version of Extensis Portfolio while building thematically-based digital collections online using CONTENTdm. The purchase of a CONTENTdm license with an unlimited item limit allowed the department to move over 10,000 images previously cataloged in Portfolio into the online environment. While metadata in the Portfolio database could be exported to a text file and immediately imported into CONTENTdm’s project client, we recognized that we had an opportunity to analyze and clean our metadata using OpenRefine as a part of the process. We also hoped to update our Portfolio database and the metadata embedded into the files themselves to reflect the results of this cleanup. This article will discuss the process we used to clean metadata in OpenRefine for ingest into CONTENTdm as well as the use of Portfolio and the VRA Panel Export-Import Tool for writing metadata changes back to the original image files

Framing Collaboration: Archives, IRs, and General Collections

Collaborative collecting highlights the opportunity for liaison librarians and archivists in academic libraries to develop an integrated and holistic approach to the successful collection of library materials. Yet as academic libraries become the central location for general collections, institutional repositories, university archives, manuscript collections, and other special collections, the world of collecting in academic libraries becomes more siloed. The profession stands to benefit from a stronger realization of shared collecting practices. Liaison librarians have the potential to provide critical information to archivists in support of faculty collecting and research. Archivists have the opportunity to provide liaison librarians with context about university units and the organization’s broader history. Shared information can result in more robust collecting policies and practices across the library

Creating A Meaningful Learning Framework for Volunteers, Internships, Practicums, and Co-ops

Presentation at Academic Library Association of Ohio Conference, Columbus, OH

Supporting Primary Source Instruction in the Undergraduate Classroom at Bowling Green State University: Summary Findings

This report presents the findings and recommendations of research conducted as a part of a study on Teaching with Primary Sources at Bowling Green State University (BGSU) during the Fall 2019 semester. It is worthy to note that this research project was conducted prior to the COVID outbreak. Along with a cohort of over two dozen institutions as part of a national study coordinated by Ithaka S+R, members of the BGSU library faculty conducted this local study with faculty who teach undergraduates with primary sources in the classroom. This report draws only on interviews conducted at BGSU. After describing the methodology employed, this report will present our findings covering four major themes identified in interviews: difficulties with primary sources, learning to work with primary sources, the role of librarians and archivists in primary source projects, and connections to information literacies. The report concludes with recommendations

The Cost of Care and the Impact on the Archives Profession

The archives profession has, in recent years, exerted considerable effort to become more welcoming and inclusive to diverse archival professionals. Many of these efforts have focused intensively on recruiting a diverse workforce. In this article, the authors propose a new approach through which to create and sustain inclusive archival work environments: caregiving. National research has shown that caregiving responsibilities affect women more than their male counterparts, and within these gender divides there are aspects of caregiving that impact individuals of different racial and cultural backgrounds unequally. The issue of navigating the demands of caregiving, work responsibilities, and professional engagement must be discussed openly and with the goal of mitigating the long-term consequences on caregivers’ health, career advancement, and financial stability. As professionals who care for archival collections, the additional demands and central importance of caregiving for loved ones incur measurable impact on archival careers. If the archival profession desires to be truly inclusive, then the issues surrounding the related factors of development opportunities, wages, and affordable care need to be confronted. This article aims to provide context for the argument that supporting caregiving responsibilities during archival employment is a crucial component of creating a wholly inclusive profession. The authors provide a literature review across disciplines, outline factors that directly influence archivists who are caregivers, and identify areas for further research

Analysis of autonomic outcomes in APOLLO, a phase III trial of the RNAi therapeutic patisiran in patients with hereditary transthyretin-mediated amyloidosis

Hereditary transthyretin-mediated (hATTR) amyloidosis is a progressive, debilitating disease often resulting in early-onset, life-impacting autonomic dysfunction. The effect of the RNAi therapeutic, patisiran, on autonomic neuropathy manifestations in patients with hATTR amyloidosis with polyneuropathy in the phase III APOLLO study is reported. Patients received patisiran 0.3 mg/kg intravenously (n = 148) or placebo (n = 77) once every 3 weeks for 18 months. Patisiran halted or reversed polyneuropathy and improved quality of life from baseline in the majority of patients. At baseline, patients in APOLLO had notable autonomic impairment, as demonstrated by the Composite Autonomic Symptom Score-31 (COMPASS-31) questionnaire and Norfolk Quality of Life-Diabetic Neuropathy (Norfolk QOL-DN) questionnaire autonomic neuropathy domain. At 18 months, patisiran improved autonomic neuropathy symptoms compared with placebo [COMPASS-31, least squares (LS) mean difference, - 7.5; 95% CI: - 11.9, - 3.2; Norfolk QOL-DN autonomic neuropathy domain, LS mean difference, - 1.1; - 1.8, - 0.5], nutritional status (modified body mass index, LS mean difference, 115.7; - 82.4, 149.0), and vasomotor function (postural blood pressure, LS mean difference, - 0.3; - 0.5, - 0.1). Patisiran treatment also led to improvement from baseline at 18 months for COMPASS-31 (LS mean change from baseline, - 5.3; 95% CI: - 7.9, - 2.7) and individual domains, orthostatic intolerance (- 4.6; - 6.3, - 2.9) and gastrointestinal symptoms (- 0.8; - 1.5, - 0.2). Rapid worsening of all study measures was observed with placebo, while patisiran treatment resulted in stable or improved scores compared with baseline. Patisiran demonstrates benefit across a range of burdensome autonomic neuropathy manifestations that deteriorate rapidly without early and continued treatment.The study was funded by Alnylam Pharmaceuticals, Inc. Medical writing services provided by Kristen Brown (PhD) of Adelphi Communications Ltd, Macclesfeld, UK were funded by Alnylam Pharmaceuticals, Inc. in accordance with Good Publication Practice (GPP3) guidelines. We would like to thank Anastasia McManus (Alnylam Pharmaceuticals, Inc.) for her assistance during preparation of this manuscript.info:eu-repo/semantics/publishedVersio

Patisiran, an RNAi therapeutic, for hereditary transthyretin amyloidosis

BACKGROUND Patisiran, an investigational RNA interference therapeutic agent, specifically inhibits hepatic synthesis of transthyretin. METHODS In this phase 3 trial, we randomly assigned patients with hereditary transthyretin amyloidosis with polyneuropathy, in a 2:1 ratio, to receive intravenous patisiran (0.3 mg per kilogram of body weight) or placebo once every 3 weeks. The primary end point was the change from baseline in the modified Neuropathy Impairment Score+7 (mNIS+7; range, 0 to 304, with higher scores indicating more impairment) at 18 months. Other assessments included the Norfolk Quality of Life-Diabetic Neuropathy (Norfolk QOL-DN) questionnaire (range, −4 to 136, with higher scores indicating worse quality of life), 10-m walk test (with gait speed measured in meters per second), and modified body-mass index (modified BMI, defined as [weight in kilograms divided by square of height in meters]×albumin level in grams per liter; lower values indicated worse nutritional status). RESULTS A total of 225 patients underwent randomization (148 to the patisiran group and 77 to the placebo group). The mean (±SD) mNIS+7 at baseline was 80.9±41.5 in the patisiran group and 74.6±37.0 in the placebo group; the least-squares mean (±SE) change from baseline was −6.0±1.7 versus 28.0±2.6 (difference, −34.0 points; P<0.001) at 18 months. The mean (±SD) baseline Norfolk QOL-DN score was 59.6±28.2 in the patisiran group and 55.5±24.3 in the placebo group; the least-squares mean (±SE) change from baseline was −6.7±1.8 versus 14.4±2.7 (difference, −21.1 points; P<0.001) at 18 months. Patisiran also showed an effect on gait speed and modified BMI. At 18 months, the least-squares mean change from baseline in gait speed was 0.08±0.02 m per second with patisiran versus −0.24±0.04 m per second with placebo (difference, 0.31 m per second; P<0.001), and the least-squares mean change from baseline in the modified BMI was −3.7±9.6 versus −119.4±14.5 (difference, 115.7; P<0.001). Approximately 20% of the patients who received patisiran and 10% of those who received placebo had mild or moderate infusion-related reactions; the overall incidence and types of adverse events were similar in the two groups. CONCLUSIONS In this trial, patisiran improved multiple clinical manifestations of hereditary transthyretin amyloidosis

College and University Archivists: Doing It All for Less

The Society of American Archivists (SAA) and its members have conducted numerous surveys of the archival profession—both of archivists as individuals and of archival institutions—through the years. In 1949, the College and University Archives Committee of SAA conducted the first survey specifically of college and university archives. Building off previous surveys, in 2021 the College and University Archives Landscape Survey was undertaken by the College and University Archives Section to gather data about the management and organization of college and university archives within the United States, as well as about the backgrounds, skills, responsibilities, and tasks in which college and university archivists are engaged. While the initial results were released to the membership, this article represents further analysis and contextualization with other professional literature. It identifies trends, similarities, and differences between surveys and eras, and it provides suggestions for future surveys and research